利用Axion Maestro研究孤独症谱系障碍( ASD )和威廉姆斯综合症(WS)

Miami( iPSC ),,Axion Maestro,线20185Scientific Reports

 

UCSDSalkiPSC(WS),20168Nature

 

Maestro( ASD )

ASD( PBMC )(hiPSCs) ;,iPSCS13535(DIV35 )135( DIV135),,( DIV35) , ASD1

 

Axion Maestro 30ASD12MEA35ASD50% ,ASD()

 

,ASD线,

 

: ASDiPSC

a.MEA:(marker ,) .

b.

c., ASD50%

 

Maestro(WS )

WS7q11.2325

WS()齿,使,V/V1

WS,,( MRI ),WS,WSWS()WS,Aysson R. MoutriWs,

 

Axion Maestro:,WS,,WS(). (2)

 

WSTD

 

:( total network burst),( spikes ineach burst ) WSTD

 

,Alysson R. Moutri,,,; 使

 

Maestro MEA

,MEA

,

,